" What seems to be clear to me is that after the primary infection most of the cells die indirectly, but at the later stage, when the viral load is very high, the virus kills a lot of cells directly. "
- Luc Montagnier

In the context provided, Luc Montagnier discusses how viruses affect human cells during different stages of an infection. He suggests that initially, most cells are damaged or destroyed indirectly as a result of the immune system's response to viral invasion rather than by direct viral action. However, when the amount of virus in the body reaches very high levels later on, it becomes more prominent for the virus itself to directly kill many cells.

Exploring deeper into this quote reveals insights about both viral pathology and immune responses. Montagnier highlights a critical transition point where indirect damage due to inflammation or other immune system activities shifts towards direct cell destruction by the virus as its presence intensifies. This understanding is vital for developing therapeutic strategies aimed at reducing viral load and managing inflammatory reactions. It underscores the complexity of viral infections, indicating that treatment approaches must address not only the virus but also the body’s own defensive mechanisms to mitigate overall damage.

Luc Montagnier, a renowned French virologist, is widely recognized for his pivotal role in identifying HIV as the causative agent of AIDS in 1983. His contributions have been instrumental in advancing our understanding of retroviruses and their impact on human health. This quote reflects his profound insights into how viruses interact with host cells at various stages of infection, underscoring his enduring influence on virology and medical science.