" We will have to make a decision, as we go into new environments outside of earth, whether we want to drag along with us all our pathogens. We can, or we can’t – it’s up to us – but I consider that part of genome engineering is how we interact with the huge part of our genome which is our microbiome. "
- George M. Church

As we venture into new environments beyond Earth, such as space stations or future colonies on other planets, a critical decision awaits us: whether to bring along all the microscopic organisms—both beneficial and harmful—that coexist within our bodies. These microorganisms, collectively known as the microbiome, play significant roles in human health, from digestion to immune function.

The deeper meaning of this statement encompasses the broader implications of genetic engineering and its potential applications beyond traditional boundaries. By considering how we interact with our microbiomes as part of genome engineering, Church suggests a future where we can manipulate these microscopic ecosystems to benefit space travel and habitation. This could mean developing strategies to eliminate harmful pathogens or cultivating beneficial bacteria that enhance resilience in challenging environments. Such advancements not only address the immediate challenges posed by microgravity and isolation but also open avenues for enhancing human health and performance across different conditions.

George M. Church is a renowned geneticist and professor at Harvard Medical School, known for his pioneering work in synthetic biology and genome sequencing technologies. His insights often bridge the gap between cutting-edge scientific research and its practical applications, making him a key figure in discussions about future biotechnological advancements, including their relevance to space exploration.