" People often ask me why I persisted in doing research on a subject that was so controversial. I frequently respond by telling them that only a few scientists are granted the great fortune to pursue topics that are so new and different that only a small number of people can grasp the meaning of such discoveries initially. "
- Stanley B. Prusiner

In simple terms, this quote conveys the idea that scientists who venture into uncharted territories often face skepticism due to the groundbreaking nature of their work. These pioneering researchers are lucky enough to explore areas where traditional knowledge does not apply and must endure criticism until others catch up with their discoveries.

Stanley B. Prusiner's words reflect a profound appreciation for the unique challenges and rewards of trailblazing scientific endeavors. By choosing to pursue controversial topics, scientists like him demonstrate resilience against doubt and opposition. This perseverance is crucial because it allows them to push the boundaries of human knowledge, even when initial acceptance is scarce. The quote also underscores the importance of patience in science; groundbreaking research takes time for others to understand and validate.

Stanley B. Prusiner, a distinguished American neurologist, made significant contributions to neuroscience through his discovery of prions—misfolded proteins responsible for causing devastating neurological diseases such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy (mad cow disease). His work was initially met with skepticism but has since been widely recognized, earning him the Nobel Prize in Physiology or Medicine in 1997.