" Inside of a living cell there are thousands of proteins that enable it to make more of itself and make your malaria drug, for instance. We don’t understand those. We don’t understand how they work together. "
- Frances Arnold

In her statement, Frances Arnold highlights a fundamental aspect of biological complexity: within living cells are numerous proteins that play critical roles in cellular reproduction and drug metabolism. These proteins interact in ways that are not yet fully understood by scientists, making it difficult to predict how they will behave or react under different conditions.

Arnold's quote touches on the intricate nature of protein function and interaction, underscoring a significant challenge in biological research. Despite extensive studies, researchers have only scratched the surface when it comes to understanding how these proteins work together within cells. This complexity poses substantial hurdles for developing effective treatments like malaria drugs, as scientists must navigate an environment where every component interacts in ways that are not yet fully known or predictable. The quote serves as a reminder of the vast amount we still need to learn about cellular biology and underscores the importance of continued research.

Frances Arnold is a renowned American chemical engineer and biochemist who has made significant contributions to the field of protein engineering. She was awarded the Nobel Prize in Chemistry in 2018 for her pioneering work on directed evolution, a method that mimics natural selection to create new enzymes with novel properties. Her insights into biological systems have been instrumental in advancing our understanding of molecular biology and biotechnology.